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michael kors outlet store Moreover, the restoration of soluble TDP43 was not due to new protein synthesis, as cycloheximide treatment prior to arsenite addition yielded a similar solubility transition (Figure 1E, lanes 5 that was reversible upon stress recovery (Figure 1E, lanes 9 To evaluate whether stressinduced ROS are responsible for decreased TDP43 solubility, cells were treated with the free radical scavenger Nacetylcysteine (NAC), which completely prevented the arsenitemediated accumulation of insoluble TDP43 (Figure 1F)..
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