Cellular pools of Rictor (mTORC2) or Raptor (mTORC1) were independently depleted using siRNA (Figure 4c). Depletion of Rictor abrogated NICGFP function (Figure 4b), whereas reducing the levels of Raptor or the scrambled siRNA (included as a control in all experiments) had no effect on NICmediated inhibition of death (Figure 4b). Although the functional interaction between mTORC2 and Notch signaling revealed by these experiments was consistent with the demonstrated requirement for Akt and its phosphorylation on S473, the requirement for mTORC2 for Notchmediated phosphorylation of Akt remained to be established.According to the National Longitudinal Study of Adolescent Health, a high IQ in childhood is associated with a higher risk of getting drunk and binge drinking. Youth who were "very bright" (with an IQ over 125) engaged in binge drinking roughly once every other month while children with an IQ below 75 engaged in binge drinking less than once a year. Showed that the m