Parentsu will have an opportunity to ask questions and give input. Refreshments and door prices will be available for parents also. There is no charge.Transactivation response (TAR) DNAbinding protein of 43 kDa (TDP43) encoded by the TARDBP gene on chromosome 1 is a major component of and ubiquitinpositive inclusions that characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to TDP43 pathology (FTLDTDP) (Neumann et al, 2006). Recent studies have identified TDP43 aggregation and neuropathology in a wide spectrum of distinct neurodegenerative disorders collectively known as TDP43 proteinopathies, supporting a central role for TDP43 in neurodegenerative disease pathogenesis (Pesiridis et al, 2009; LagierTourenne et al, 2010). Currently, missense mutations in the TARDBP gene have been identified as being pathogenic for familial and sporadic ALS as well as in rare familial cases of ALS and FTLDTDP (LagierTourenne and Cleveland, 2009; Pesiri