The analysts agree that teams with plenty of veterans and continuity in their coaching staffs will have an edge, at least early in the season. Mariucci, noting there are 27 new team offensive and defensive coordinators, expects more lopsided games than usual when veteran teams play teams more in transition pointing to Fox's Green Bay Packers at Carolina Panthers in Week 2 as a likely candidate. Says Mariucci, "The first part of the season will be a completely different type of month than we're used to.".In this article, we provide an overview of the acute and longterm pathophysiology of singleincident and repetitive TBI, focusing in particular on chronic traumatic encephalopathy (CTE). We briefly discuss imaging as well as plasma and cerebrospinal fluid (CSF) biomarkers for this disorder, and finally consider preventive measures that can be undertaken to avoid such injury. Understanding of the issues discussed will assist clinical and research communities to manage the ri