michael kors black Friday An increase in this ratio indicates BBB damage, which is found in patients with various CNS disorders, such as infections, inflammatory diseases, brain tumours or cerebrovascular diseases.48Two studies have shown an increase in the CSF:serum albumin ratio in patients with severe TBI associated with a neuroinflammatory response.51, 52 By contrast, no such changes have been seen in studies of mild TBI in boxers and military personnel with blast exposure,53, 54 suggesting that the BBB remains intact in individuals with mild TBI.NeuroinflammationThe findings of a large number of studies confirm that an acute inflammatory response occurs within the CNS after severe TBI, which is reflected in the concentrations of various CSF components.51, 52, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64 In general, levels of inflammatory proteins, such as IL6, IL8 and IL10, are increased in CSF in response to severe TBI. The magnitude of th